If the change is an Emergent Event.
Emergent Events change everything at the level of their scope which can be Fact, Theory, Paradigm, Episteme, Ontos, Existence, Absolute
Anything that is a Paradigm Change or higher could be monumental.
Reference for Emergence: The Philosophy of the Present by G.H. Mead
See the Structure of Theoretical Systems in relation to Emergence by myself.